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Changes of lipoxin levels during pregnancy and the monthly-cycle, condition the normal course of pregnancy or pathology.
Szczuko M, Palma J, Kikut J, Komorniak N, Ziętek M. Szczuko M, et al. Inflamm Res. 2020 Sep;69(9):869-881. doi: 10.1007/s00011-020-01358-6. Epub 2020 Jun 2. Inflamm Res. 2020. PMID: 32488315 Free PMC article. Review.
Ovulation, menstruation, embryo implantation, and childbirth are reactions representing short-term inflammatory events involving lipoxin activities. Lipoxin A4 (LXA4) is an arachidonic acid metabolite, and in cooperation with its positional isomer lipoxin B4 …
Ovulation, menstruation, embryo implantation, and childbirth are reactions representing short-term inflammatory events involving lipoxin act …
Expression of lipoxin A4, TNFalpha and IL-1beta in maternal peripheral blood, umbilical cord blood and placenta, and their significance in pre-eclampsia.
Dong W, Yin L. Dong W, et al. Hypertens Pregnancy. 2014 Nov;33(4):449-56. doi: 10.3109/10641955.2014.931419. Epub 2014 Jun 24. Hypertens Pregnancy. 2014. PMID: 24960456
No lipoxin A4 was detected in umbilical cord blood. There was a significant increase in FPR2/ALX mRNA expression in placenta obtained from the PE groups. CONCLUSIONS: The level of lipoxin A4 in maternal peripheral blood may correlate with the ex …
No lipoxin A4 was detected in umbilical cord blood. There was a significant increase in FPR2/ALX mRNA expression in placent …
Infection with Listeria monocytogenes alters the placental transcriptome and eicosanome.
Conner KN, Holman D, Lydic T, Hardy JW. Conner KN, et al. Placenta. 2022 Oct;128:29-35. doi: 10.1016/j.placenta.2022.08.001. Epub 2022 Aug 23. Placenta. 2022. PMID: 36057170
Infected and control placentas were collected on embryonic day 18 for RNA sequencing to evaluate gene expression signatures associated with infection by Listeria. ...Because of the known importance of eicosanoids in inflammation and timing of labor, we quantified eicosanoi …
Infected and control placentas were collected on embryonic day 18 for RNA sequencing to evaluate gene expression signatures associate …
Preeclampsia is associated with a deficiency of lipoxin A4, an endogenous anti-inflammatory mediator.
Xu Z, Zhao F, Lin F, Xiang H, Wang N, Ye D, Huang Y. Xu Z, et al. Fertil Steril. 2014 Jul;102(1):282-290.e4. doi: 10.1016/j.fertnstert.2014.03.056. Epub 2014 May 3. Fertil Steril. 2014. PMID: 24796762 Free article.
OBJECTIVE: To test whether lipoxin A4 (LXA4) deficiency results in preeclampsia. DESIGN: Prospective experimental study. ...ANIMAL(S): Sprague-Dawley rats. INTERVENTION(S): We measured LXA4 and its biosynthetic enzymes, blocked the LXA4 signalin …
OBJECTIVE: To test whether lipoxin A4 (LXA4) deficiency results in preeclampsia. DESIGN: Prospective experimental study …
Formyl-peptide receptor 2 suppresses proliferation, migration and invasion in human extravillous trophoblastic cells.
Zhao S, Liao T, Zhou T, Huang X, Xiang H, Chen J, Xu Z. Zhao S, et al. Prostaglandins Other Lipid Mediat. 2019 Aug;143:106342. doi: 10.1016/j.prostaglandins.2019.106342. Epub 2019 Jun 6. Prostaglandins Other Lipid Mediat. 2019. PMID: 31176799
Although FPR2 receptor is distributed in the endometrium and placenta, its function in human extravillous trophoblastic (TEV-1) cells still remains enigmatic. ...
Although FPR2 receptor is distributed in the endometrium and placenta, its function in human extravillous trophoblastic (TEV-1) cells …
Glucocorticoids sensitize rat placental inflammatory responses via inhibiting lipoxin A4 biosynthesis.
Zhang D, Li Y, Peng H, Liu H, Cheng Q, Cheng X, Zeng P, Wu P, Chen H, Huang Y, Ye D. Zhang D, et al. Biol Reprod. 2014 Apr 10;90(4):74. doi: 10.1095/biolreprod.113.116384. Print 2014 Apr. Biol Reprod. 2014. PMID: 24571985
Inflammation dysregulation in placenta is implicated in the pathogenesis of numerous pregnancy complications. ...Mechanically, Dex pretreatment promoted 5-lipoxygenase (ALOX5) activation and increased leukotriene B4 production, whereas it inhibited the anti-inflammatory an …
Inflammation dysregulation in placenta is implicated in the pathogenesis of numerous pregnancy complications. ...Mechanically, Dex pr …
The Effect of BML-111 in Preeclampsia Rat Model Induced by the Low Dose of Cadmium Chloride.
Zhang K, Hu M, Zhang L, Zhang Q, Huang Y. Zhang K, et al. AJP Rep. 2019 Jul;9(3):e201-e208. doi: 10.1055/s-0039-1693016. Epub 2019 Jul 4. AJP Rep. 2019. PMID: 31281736 Free PMC article.
Aim This article determines the optimal time and dose of cadmium chloride (CdCl (2) ) injected to pregnant rat to establish experimental preeclampsia (PE) model. In addition, the therapeutic potential of BML-111, a lipoxin A4 analogue, in the CdCl (2) -induced PE mo …
Aim This article determines the optimal time and dose of cadmium chloride (CdCl (2) ) injected to pregnant rat to establish experimental pre …
Expression of anti-inflammatory mediator lipoxin A4 and inflammation responsive transcriptive factors NF-kappa B in patients with preeclampsia.
Huang LL, Su S, Awale R, Zhang XY, Zhong LL, Tang H. Huang LL, et al. Clin Exp Obstet Gynecol. 2014;41(5):561-6. Clin Exp Obstet Gynecol. 2014. PMID: 25864260
OBJECTIVE: To evaluate the role of lipoxin A4 (LXA4), NF-kappaB p65 in preeclampsia. MATERIALS AND METHODS: LXA4 in blood serum and the lipoxin A4 receptor (ALX-R), NF-kappaB p65 mRNA, protein expressions in placenta-specific tissu …
OBJECTIVE: To evaluate the role of lipoxin A4 (LXA4), NF-kappaB p65 in preeclampsia. MATERIALS AND METHODS: LXA4 …
A synthetic analog of lipoxin A4 partially alleviates dexamethasone-induced fetal growth restriction in rats.
Lin F, Yu X, Zhang X, Guo Y, Huang Y, Zhou J, Zeng P, Ye D, Huang Y. Lin F, et al. Placenta. 2013 Oct;34(10):941-8. doi: 10.1016/j.placenta.2013.07.007. Epub 2013 Aug 1. Placenta. 2013. PMID: 23910525
There is evidence to show that FGR is associated with oxidative stress. Lipoxin A4 (LXA4) is an anti-inflammatory mediator and is considered to be a potent endogenous "stop signal" in inflammation. ...Recently, the antioxidant effect of LXA4 on a varie …
There is evidence to show that FGR is associated with oxidative stress. Lipoxin A4 (LXA4) is an anti-inflammatory media …
17 results